DNA Replication Enzymes and Inner Fish

For homework we were asked to read Ch. 3 of Your Inner Fish and post a summary. In chapter 3, it discusses how there are hundreds of cells that help develop tissues and organs within their shapes and various functions. Even though all the cells are very different, they have identical DNA. The only reason behind the fact that the  cells don't come out identical is that each of the different cells has genes that are inactive and active. The whole body is made up of genes that can activate or turn on and off, that create our development. Many of these genes were tested out on animals. They took a protein from a mouse and inserted it into a shark embryo which was received as one of his own. This shows the connection and development between all living creatures and their genes.


DNA Replication Enzymes:

There are 5 enzymes that take part in the replication of DNA:

1.) Helicase
2.) RNA Primase
3.) DNA Polymerase III
4.) DNA Polymerase I
5.) Ligase

How They Work: 

1.) Helicase works by "unzipping" the DNA. It is the first step in replication. It works by breaking the hydrogen bonds that are between the two nitrogen bases in the DNA.
2.) RNA Primase then comes in after and lays down/inserts complementary RNA from the 3' -> 5'
3.) DNA Polymerase III puts down complementary nucleotides
4.) DNA Polymerase I will come in during the replication and remove all the RNA from the lagging strand
5.) The ligase acts as a glue in the replication and recreates the phosphodiester bonds




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